Multifunctional Nanoparticles for Drug Delivery and Molecular Imaging

Multifunctional Magnetic Nanoparticles for Imaging and Drug Delivery

One of the limitations in the drug delivery field is the inability to specifically target therapeutic or imaging agents to certain tissues, organs or tumors. Magnetic nanoparticles have emerged as effective drug delivery systems, which can be directed by externally applied magnetic fields and specifically tailoring their functional properties. Unfortunately, available magnetic nanoparticles wit...

Molecular imaging with multifunctional nanoparticles.

Featured Article: Gao XH, Cui YY, Levenson RM, Chung LWK, Nie SM. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotechnol 2004;22:969 –76. The development of high-sensitivity and highspecificity probes that transcend the intrinsic limitations of organic fluorophores has been highly sought after by scientists in fields ranging from basic biology to molecular imaging ...

Synthesis and characterization of multifunctional hybrid-polymeric nanoparticles for drug delivery and multimodal imaging of cancer

In this study, multifunctional hybrid-polymeric nanoparticles were prepared for the treatment of cultured multicellular tumor spheroids (MCTS) of the PANC-1 and MIA PaCa-2 pancreatic carcinoma cell lines. To synthesize the hybrid-polymeric nanoparticles, the poly lactic-co-glycolic acid core of the particles was loaded with Rhodamine 6G dye and the chemotherapeutic agent, Paclitaxel, was incorp...

Multifunctional nanoparticles for photothermally controlled drug delivery and magnetic resonance imaging enhancement.

Enzyme-responsive multifunctional magnetic nanoparticles for tumor intracellular drug delivery and imaging.

Enzyme-responsive, hybrid, magnetic silica nanoparticles have been employed for multifunctional applications in selective drug delivery and intracellular tumor imaging. In this study, doxorubicin (Dox)-conjugated, enzyme-cleavable peptide precursors were covalently tethered onto the surface of uniform silica-coated magnetic nanoparticles through click chemistry. This enzyme-responsive nanoparti...